报告内容摘要：

Bacterial infections and the ensuing complications often result in the failure of implants used for repair or replacement of hard tissue; such infections are traditionally treated by systemic antibiotic therapy. However, the abuse of antibiotics has been reported to induce bacterial resistance and even multidrugresistant superbugs. In addition, once protective bacterial biofilms form on the surface of implants, antibiotic therapy have been reported to have poor outcome. The coating strategy is proposed to prevent implant-related bacterial infections because functionalized coatings can endow the implant materials with highly effective self-antibacterial efficacy. Our recent studies developed a series of photo-sensitive surface systems such as Graphene Oxide/Ag/Collagen, Tannic Acid/Fe3+/Ag, black phosphorus nanosheets (BPSs)/poly (4-pyridonemethylstyrene) endoperoxide (PPMS-EPO), Chitosan/MoS2, Ag@AgCl and so on, in which lights with different wavelengths can inspire the photocatalytic or/and photothermal properties of coatings to produce large amount of radical oxygen species (ROS) or hyperthermia through electron transition or oscillations during light irradiation. ROS and/or hyperthermia can kill the bacteria directly by damaging the bacterial membrane and the inside masses such as proteins and DNA, thus endowing the coatings with highly photodynamic and photothermal antibacterial ability. Sometimes, photothermal and photodynamic therapy for bacterial infection can be combined with each other or other techniques, thus exhibiting desirable synergistic effects for antibacterial therapy and tissue repair or reconstructions.

报告人简介：

吴水林，天津大学材料科学与工程学院教授，博士生导师，国家优秀青年基金获得者，2007年毕业于香港城市大学，获工学博士学位。吴水林主要从事医用金属材料及其表面功能化改性研究，在多孔镍钛合金、纳米仿生支架材料以及人工骨组织工程，界面生物学等领域开展了多项研究，近年来专注钛金属植入体表面的功能化改性以及抗菌材料的研究工作。已经在Advanced Materials，Adv. Funct. Mater.、 Prog. Mater. Sci.、 Mater. Sci. Eng. R、ACS Nano、ACS Central Science、Biomaterials等国际权威期刊上发表论文130多篇，SCI引用超过3000次，H因子33, ESI高被引论文3篇，授权中国发明专利5项。主持973预研项目以及国家重点研发计划项目课题、湖北省杰出青年基金项目等。

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